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KMID : 1216720120040020132
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Korean Journal of Gynecologic Endocrinology
2012 Volume.4 No. 2 p.132 ~ p.139
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The Relationship between Interleukin-10 .592A>C Polymorphism, Bone Mineral Density and Bone Response after Hormone Therapy in Postmenopausal Korean Women
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Kim Hoon
Koh Ha-Nee
Ku Seung-Yup
Kim Seok-Hyun
Choi Young-Min
Kim Jung-Gu
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Abstract
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Objectives: To investigate the association between interleukin (IL)-10 -592A>C gene polymorphisms, pre-hormone therapy (HT) and post-HT bone mineral density (BMD) and biochemical bone markers and in postmenopausal Korean women
Methods: The IL-10 -592A>C polymorphism was analyzed by Taqman assay in 373 postmenopausal Korean women. Serum biochemical markers including CrossLaps (CTX) and bone alkaline phosphatase (BAP) and serum osteoprotegerin (OPG)-soluble receptor activator of nuclear factor-kB (sRANKL) were measured by enzyme linked immunosorbent assay. The BMD was determined at the lumbar spine (LS) and femoral neck (FN) by dual energy X-ray absorptiometry. BMDs and bone markers were also measured after HT.
Results: No significant differences were found in adjusted BMD at LS and FN or in risk for osteoporosis according to the genotypes of the IL-10 -592A>C polymorphism. Statistical significances were neither observed in serum levels of bone chemical markers and serum OPG-sRANKL. There were no significant differences in change of BMD or bone markers after HT according to the genotypes of the IL-10 -592A>C polymorphism.
Conclusion: The IL-10 -592A>C polymorphism did not demonstrate a significant effect on BMD at the lumbar spine and femoral neck in postmenopausal Korean women.
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KEYWORD
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Bone biochemical markers, Bone mineral density, Genetic polymorphism, Hormone therapy, IL-10
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